Saturday, February 4, 2012

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Source: http://house-home-centired.co.za/2012/02/different-types-of-cheap-gaming-computers/

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Egyptian protesters blame police for soccer deaths

Egyptian protesters stand on a cement block barrier separating the interior ministry from Tahrir Square, Cairo, Egypt Thursday, Feb. 2, 2012. Egyptian police fired tear gas Thursday at thousands of demonstrators outside the Interior Ministry protesting the security forces' failure to prevent a soccer riot that killed more than 70 people.(AP Photo/Khalil Hamra)

Egyptian protesters stand on a cement block barrier separating the interior ministry from Tahrir Square, Cairo, Egypt Thursday, Feb. 2, 2012. Egyptian police fired tear gas Thursday at thousands of demonstrators outside the Interior Ministry protesting the security forces' failure to prevent a soccer riot that killed more than 70 people.(AP Photo/Khalil Hamra)

Egyptian protestors run from tear gas fired by security forces during clashes near the interior ministry in downtown Cairo, Egypt, Thursday, Feb. 2, 2012. Egyptian police fired tear gas Thursday at thousands of demonstrators outside the Interior Ministry protesting the security forces' failure to prevent a soccer riot that killed more than 70 people.(AP Photo/Khalil Hamra)

Egyptian protestors run from tear gas fired by security forces during clashes near the interior ministry in downtown Cairo, Egypt, Thursday, Feb. 2, 2012. Egyptian police fired tear gas Thursday at thousands of demonstrators outside the Interior Ministry protesting the security forces' failure to prevent a soccer riot that killed more than 70 people.(AP Photo/Khalil Hamra)

An Egyptian protestor flashes the victory sign as he stands near a bonfire during clashes with the security forces near the interior ministry in downtown Cairo, Egypt, Thursday, Feb. 2, 2012. Egyptian police fired tear gas Thursday at thousands of demonstrators outside the Interior Ministry protesting the security forces' failure to prevent a soccer riot that killed more than 70 people. (AP Photo/Khalil Hamra)

An Egyptian protestor throws a tear gas canister during clashes with the security forces near the interior ministry in downtown Cairo, Egypt, Thursday, Feb. 2, 2012. Egyptian police fired tear gas Thursday at thousands of demonstrators outside the Interior Ministry protesting the security forces' failure to prevent a soccer riot that killed more than 70 people.(AP Photo/Khalil Hamra)

(AP) ? Security forces clashed Thursday with stone-throwing protesters enraged by the failure of police to prevent a soccer riot that killed 74 people, as sports violence spiraled into a new political crisis for Egypt.

The deaths Wednesday night in a post-match stadium riot in the Mediterranean city of Port Said fueled anger at Egypt's ruling military and the already widely distrusted police forces. Many in the public and in the newly elected parliament blamed the leadership for letting it happen ? whether from a lack of control or, as some alleged, on purpose.

Survivors of the riot described a nightmarish scene in the stadium. Police stood by doing nothing, they said, as fans of the winning home team, Al-Masry, attacked supporters of the top Cairo club, Al-Ahly, stabbing them and throwing them off bleachers.

A narrow exit corridor turned into a death trap as crowds of fans fled into it, only to be crushed against a locked gate as their rivals attacked them from behind.

A network of zealous Al-Ahly soccer fans known as Ultras vowed vengeance, accusing the police of intentionally letting rivals attack them because they have been among the most aggressive of Egypt's revolutionaries. Ultras were at the forefront of the anti-government uprising ? first against toppled leader Hosni Mubarak a year ago and now against the military that took his place in power.

"Either they will die or we will die," one Ultra said, referring to the police, as he joined a march by some 10,000 people on the Cairo headquarters of the Interior Ministry, which oversees the security forces. He would only give his first name, Islam, for fear of reprisal by police.

The march turned into a call for the ruling military council of generals, led by Field Marshal Hussein Tantawi, to surrender power.

"Say it out loud, the council must leave!" the marchers chanted, shouting to people in residential buildings along the way. "Get down from your balconies, Tantawi killed your children!"

The military has faced protests for months led by secular and liberal youth groups demanding an end to its rule ? and the soccer riot added to criticism that the generals have mismanaged the transition from Mubarak's rule. Opponents accuse the generals of being as autocratic as the ousted president and of preserving much of his regime. They say elements in the police and former regime figures have been working behind the scenes to undermine the revolution and prevent real change.

"We dreamed of change. They fooled us and brought us a field marshal instead," protesters chanted Thursday as they reached the Interior Ministry, near Tahrir Square. Some called for the execution of the military rulers. Many raised flags of the Al-Ahly club and Zamalek, another top Cairo team with its own group of Ultras.

The crowds approached the ministry from multiple sides. Some tried to dismantle walls of large concrete blocks that had been erected on streets leading to the ministry after November clashes. Others tore away barbed wire barriers.

Protesters hurled stones at lines of riot police, who responded with heavy barrages of tear gas that sent the crowd scattering, some passing out and falling. Protesters set tires on fire, sending up black smoke as motorcyclists ferried away the injured. One young man who climbed atop a traffic light waving a flag was unmoved even as he was engulfed in a cloud of gas.

"We are just across the street from the ministry," said one protester, Taha Mahfouz, wearing a helmet and waving a club that he had taken from riot police. "They can't protect their own stuff. How can they protect the country?"

The Health Ministry said 388 protesters were injured, most overcome by gas.

In an emergency session of parliament, several lawmakers said the police failure to stop the rioting was intentional, aimed at stoking insecurity since Mubarak's ouster on Feb. 11, 2011. The aim, they said, was to create instability to justify maintaining strict emergency laws.

"This is a complete crime," said Abbas Mekhimar, head of parliament's defense committee. "This is part of the scenario of fueling chaos against Egypt."

Prime Minister Kamal el-Ganzouri told parliament he had dissolved the Egyptian Soccer Federation's board and referred its members for questioning by prosecutors about the violence. He also said the governor of Port Said province and the area's police chief have resigned.

Tantawi told reporters Wednesday that the country's transition will not be derailed by the violence.

"Egypt is going down the path we planned," he said. "We will continue down this path and we will get through this transition."

Security officials said 47 people were arrested in Port Said. Ismail el-Iskandarani, a researcher with the private group Egyptian Initiative for Personal Rights who was in Port Said, said 17 of the dead remain unidentified and at least three of those killed were residents of Port Said, and not Al-Ahly sports fans.

The soccer violence ? the world's deadliest in 15 years ? began when Al-Masry pulled out a surprise 3-1 victory over Al-Ahly, Egypt's most powerful club. Al-Masry fans stormed the field, rushing past lines of police to attack Al-Ahly's Ultras.

"I saw death with my own eyes. I saw people take their last breath," said Samir Saad, a 27-year old Al-Ahly fan who was stabbed in the leg as he fled into the stands. "The security opened the doors for Al-Masry fans and closed (them) in our face."

Others reported Al-Ahly fans being thrown from the stands or jumping to escape. Some said Al-Masry supporters carved the words "Port Said" into the bodies of stricken fans.

Authorities shut off the stadium lights, plunging it into darkness. In the exit corridor, the fleeing crowd pressed against a chained gate until it broke open.

"Everyone was pushing. Under me were more than three people and I am being pushed. Everyone is pushing trying to breathe," said Mahmoud Ibrahim, who was trapped in the corridor. He spoke at Cairo's main morgue where many of the dead were taken, including two of his friends.

There was bad blood between the two teams even before the match, and many were itching for a fight. Early in the game, Ultras raised a banner reading, "Port Said is a garbage city and has no men," before it was quickly taken down.

Ultras accused police of failing to do the usual searches for weapons, and witnesses reported fans in the Al-Masry stands had clubs and knives. El-Iskandarani, the rights worker investigating the violence, said witnesses reported that some of those carrying knives were known locally as thugs-for-hire.

Pedro Barny, a Portuguese assistant to Al-Ahly coach Manuel Jose, complained of a lack of security as the tensions mounted during the game.

"The atmosphere was very aggressive. It was very intimidating for our team," Barny told Radiotelevisao Portuguesa. "There were opposition fans walking up and down unchallenged in front of our bench during the game and the police did nothing."

He said there was a charge across pitch toward the Al-Ahly fans that collided with the players and coaches. "I ran and ran to get away from it."

He said he was punched and kicked as he sprinted for the tunnel.

The Ultras are among Egypt's rowdiest fans and are proud of their hatred for the police, who were the backbone of Mubarak's authoritarian rule. During matches, they are known for their obscenity-laced anti-police songs and chants, which usually go viral on the Internet, an expression of the hatred many Egyptians feel toward the security forces.

The network is highly organized across the country, but they were long apolitical, resenting the police for friction at soccer matches. When the uprising began, the Ultras used their years of experience in clashing with police at stadiums to help defend protesters against attacks by security forces and regime supporters.

After Mubarak's fall, they joined protests against the military, and in November and December, they fought back against troops cracking down on demonstrations in clashes that left dozens dead. Ironically, the revolution has united the Ultra backers of the Al-Ahly and Zamalek clubs, the country's most bitter soccer rivalry.

Ahmad Saqqar, a 22-year-old Ultra wearing a red Al-Ahly shirt, said the Ultras are "all about resisting police suppression."

"The military plotted yesterday to take revenge on us," he said. "We know how to respond ... after we recover from our wounds."

___

Associated Press Writer Aya Batrawy contributed to this report.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2012-02-02-ML-Egypt/id-3b9262cb0670415f80b0b7947cf80077

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Friday, February 3, 2012

Supporters rally around Planned Parenthood (AP)

NEW YORK ? Supporters are rallying around Planned Parenthood after renowned breast cancer charity Susan G. Komen for the Cure decided to cut breast screening grants to the reproductive health organization.

Besides $400,000 in smaller donations from 6,000 people, Planned Parenthood is receiving $250,000 from a family foundation in Dallas and a $250,000 pledge announced Thursday by New York Mayor Michael Bloomberg to match future donations.

In Washington, 26 U.S. senators ? all Democrats except for independent Bernie Sanders of Vermont ? signed a letter calling on Komen to reconsider its decision.

"It would be tragic if any woman ? let alone thousands of women ? lost access to these potentially lifesaving screenings because of a politically motivated attack," the senators wrote.

According to Planned Parenthood, its health centers performed more than 4 million breast exams over the past five years, including nearly 170,000 as a result of Komen grants.

Komen, meanwhile, has been deluged with negative emails and Facebook postings, accusing it of knuckling under to pressure from anti-abortion groups, since The Associated Press reported on Tuesday that the charity was halting grants that Planned Parenthood affiliates used for breast exams and related services. The grants totaled $680,000 last year.

Some of Komen's local affiliates were openly upset, including all seven in California, and at least one top official has quit, reportedly in protest.

Komen's top leaders, in their first news conference since the controversy erupted, denied Planned Parenthood's assertion that the decision was driven by pressure from anti-abortion groups.

"We don't base our funding decisions ... on whether one side or the other will be pleased," said Komen's founder and CEO, Nancy Brinker, depicting the criticism as a mischaracterization of the charity's goals and mission.

Komen has said the decision stemmed from newly adopted criteria barring grants to organizations under investigation ? affecting Planned Parenthood because of an inquiry by a Republican congressman acting with encouragement from anti-abortion activists.

Brinker said Thursday there were additional factors, notably changes in the types of breast-health service providers it wanted to support. But she said grants would continue this year to three of the 19 Planned Parenthood affiliates ? in Denver, California's Orange County, and Waco, Texas ? because they served clientele with few other breast-screening options.

A source with direct knowledge of decision-making at Komen's headquarters in Dallas gave a different account, saying the grant-making criteria were adopted with the deliberate intention of targeting Planned Parenthood. The criteria's impact on Planned Parenthood and its status as the focus of government investigations were highlighted in a memo distributed to Komen affiliates in December.

According to the source, who spoke on condition of anonymity for fear of repercussions, a driving force behind the move was Karen Handel, who was hired by Komen last year as vice president for public policy after losing a campaign for governor in Georgia in which she stressed her anti-abortion views and frequently denounced Planned Parenthood.

Brinker, in an interview with MSNBC, said Handel didn't have a significant role in the policy change.

The source also said that Mollie Williams, who had been Komen's director of community health programs, had resigned in protest over the grant cutoff.

Williams, in an email, said she could not comment on her departure for reasons of professional confidentiality, but she was clear about her views.

"I have dedicated my career to fighting for the rights of the marginalized and underserved," she wrote. "And I believe it would be a mistake for any organization to bow to political pressure and compromise its mission."

Williams said she was saddened by the rift because she admired both Komen and Planned Parenthood.

"I am hopeful their passionate and courageous leaders, Nancy Brinker and Cecile Richards, can swiftly resolve this conflict in a manner that benefits the women they both serve."

Among Komen's affiliates, there were clear signs of discomfort with the decision. The Connecticut branch received scores of supportive emails after expressing frustration about the cutoffs and good will toward Planned Parenthood.

All seven Komen affiliates in California, in a joint letter to their congressional delegation, said they were "strongly opposed" to the policy change and were working to overturn it.

"Our commitment to our mission is unwavering," the letter said. "This is a misstep in that journey and ... we will do whatever it takes to do what is right for the health of women and men in California."

In New York City, a member of the Komen affiliate's medical advisory board said she would resign if the decision wasn't changed soon.

"Komen is a wonderful organization and does tremendous things for women, but this is straying from their mission," said Dr. Kathy Plesser, a radiologist. "It's sad."

The board of the Arkansas affiliate issued a statement noting that the decision was made at Komen headquarters "without input from affiliates," and called for the new policy to be changed.

"We hope Komen national will reverse its position on granting to organizations under investigation because we feel decisions of this nature should be made only after the investigation is complete," the statement said.

At the Orange County affiliate in Costa Mesa, Calif., executive director Lisa Wolter said there have been lots of exchanges with headquarters.

"We're very troubled by the reaction, and we want to make sure there are clarifications," she said.

The American Association of University Women, in protest over Komen's decision, said it was scrapping plans to offer a Komen Race for the Cure as one of the activities at its upcoming National Conference for College Women Student Leaders.

"AAUW is disappointed that some are playing politics with women's health and jeopardizing care for the most vulnerable among us," said Lisa Maatz, the association's director of public policy.

Though comments posted on Komen's Facebook page seemed to be mostly critical of the grant decision, Brinker said at her news conference that donations to the charity had increased since Tuesday.

She also said there were other organizations receiving Komen grants that might be adversely affected by the new criteria about investigations, but she did not identify them.

___

Online:

Susan G. Komen for the Cure: http://ww5.komen.org/

Planned Parenthood: http://www.plannedparenthood.org/

___

David Crary can be followed on Twitter at http://twitter.com/CraryAP

Source: http://us.rd.yahoo.com/dailynews/rss/diseases/*http%3A//news.yahoo.com/s/ap/20120203/ap_on_he_me/us_planned_parenthood_komen

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Avid Studio rolls onto iPad, treads on iMovie's toes (video)

There may be a number of options for budding iPad Scorseses, now you can add Avid's "Studio" to that list. Conveniently launching at the same price as iMovie, Avid's intention to woo Apple's users is clear. Those five bucks get you a tidy storyboard solution, "precision" editing, the usual array of transitions and effects, plus multi-channel audio support (including access to your iTunes library). Video can be shot from the device itself, of course, and camera kit owners can import footage from your archives. The final results can then be rendered in either 480p, 540p and 720p or shared via the usual social options. Most importantly, projects can also be finished off in the desktop version -- handy, if they start getting into Titanic territory. It's available today, just focus your iPad at the app store (or the source link below).

Continue reading Avid Studio rolls onto iPad, treads on iMovie's toes (video)

Avid Studio rolls onto iPad, treads on iMovie's toes (video) originally appeared on Engadget on Fri, 03 Feb 2012 01:43:00 EDT. Please see our terms for use of feeds.

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Source: http://www.engadget.com/2012/02/03/avid-studio-ipad-version/

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Thursday, February 2, 2012

Freighter sinks off Turkish coast, 9 crew missing (AP)

ANKARA, Turkey ? Turkish Coast Guard boats were searching for nine crew members after a Cambodia-flagged freighter ship sank in stormy seas off Turkey's Black Sea coast on Tuesday, officials said. Two other crew members were rescued.

The ship, Vera, was sailing to Turkey's Aliaga port from Russia when it sank off the coast of Eregli during a storm, Gov. Erol Ayyildiz said. He said police were also searching the shore for the missing crewmen.

Ayyildiz initially said 10 crew were missing and that they were Polish nationals. But the Maritime Affairs Directorate later said there were 10 Ukrainians and one Georgian crew aboard the ship, which was carrying scrap metal.

Those rescued were the ship's second and third captains, the directorate said in a statement. At least three tug boats had joined the search-and-rescue effort, it added.

"By the time the Coast Guard arrived in response to the distress call, the ship had already sunk," Irfan Erdem, head of the Chamber of Commerce for the region, told Turkey's NTV television.

He said a storm likely caused the ship's cargo to shift, tilting the vessel to the side and causing it to take on water.

The accident occurred some 10 days after another cargo ship brushed against two anchored vessels during severe weather off the coast of Istanbul, taking on water for hours before authorities pulled it ashore using a tug boat.

Source: http://us.rd.yahoo.com/dailynews/rss/europe/*http%3A//news.yahoo.com/s/ap/20120131/ap_on_re_eu/eu_turkey_ship_sinks

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Kevin Bacon to star in Kevin Williamson's Fox TV pilot (Reuters)

LOS ANGELES, Feb 1 (TheWrap.com) ? Kevin Bacon is now zero degrees of separation from Kevin Williamson.

The "Crazy, Stupid Love" actor will star in "Dawson's Creek" creator Kevin Williamson's upcoming pilot for Fox, an individual with knowledge of the casting confirms to The Wrap.

The drama pilot is described as "an edge-of-the-seat thriller about a diabolical serial killer who uses technology to create a cult of serial killers, and the ex-FBI agent who finds himself in the middle of it." Bacon will play the former FBI agent.

As part of the deal, the pilot, if picked up to series, will run 15 episodes per season instead of the typical 22, so that Bacon will have the freedom to pursue feature films and other projects of interest. Bacon's upcoming film projects include the drama "Jayne Mansfield's Car" and the action comedy "R.I.P.D."

Warner Bros. Television is producing.

Deadline first reported the news.

(Editing By Zorianna Kit)

Source: http://us.rd.yahoo.com/dailynews/rss/tv/*http%3A//news.yahoo.com/s/nm/20120202/tv_nm/us_kevinbacon

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Wednesday, February 1, 2012

Jak of all trades? Not of leukaemia therapy!

Monday, January 30, 2012

About one in five or six cases of adult leukaemia in Western populations relates to so-called chronic myeloid leukaemia, or CML. Treatment of CML usually relies on inhibitors of the abnormal protein that causes the condition but some patients do not respond to treatment and efforts are underway to develop a supplementary approach, targeting the so-called JAK2 kinase. Recent results from the groups of Veronika Sexl at the University of Veterinary Medicine, Vienna (Vetmeduni Vienna) and Giulio Superti-Furga at the Research Center for Molecular Medicine of the Austrian Academy of Sciences (CeMM) have called this strategy into question. The work is published in the current issue of the prestigious journal Nature Chemical Biology and is of immediate relevance to leukaemia treatment.

The cause of CML has been known since 1960, when two scientists in Philadelphia, Pennsylvania showed that the disease was associated with a particular genetic abnormality, the "Philadelphia chromosome". Philadelphia chromosomes represent the result of an incorrect crossing-over between two chromosomes, through which part of the Bcr ("breakpoint cluster region") gene from chromosome 22 fuses with the Abl gene on chromosome 9. The fusion gene product is a tyrosine kinase, i.e. it can phosphorylate other proteins on tyrosine residues. When it does so, it incorrectly activates several signal pathways controlling cell division in white blood cells and leads to leukaemia. Thankfully, drugs have been developed that prevent the kinase activity of the BCR-ABL fusion protein and the majority of patients treated with such tyrosine kinase inhibitors (e.g. imatinib) show no further signs of leukaemia.

Unfortunately, however, patients may develop resistance to the therapy so an alternative approach is required. Recent developments have focused on the use of drugs targeting another kinase involved in CML, the JAK2 kinase. In normal white blood cells, JAK2 is known to activate a further molecule, known as STAT5, which is absolutely required for the development of CML. The argument runs that if JAK2 could be specifically inhibited ? and thus STAT5 not activated ? it would bring fresh hope to patients who do not respond to treatment with imatinib. Several potential inhibitors of JAK2 are currently undergoing clinical trials and may shortly be available for treating patients.

The theory is appealing but to date we do not really understand exactly what happens when JAK2 is inactivated following the initiation of leukaemia by the Bcr-Abl oncogene. Sexl and her colleagues have used a transgenic mouse model to clarify the functions of these proteins in leukaemia. Their results were highly unexpected. The JAK2 kinase was found to be not required for the maintenance of the disease, i.e. inhibiting JAK2 in leukaemic cells had no therapeutic benefit. However, inhibition of STAT5 in leukaemia was sufficient to prevent cell proliferation. As Sexl says, "this means that the normal signalling pathway is completely rewired in CML cells: STAT5 activity no longer depends on JAK2." In support of this conclusion, the researchers were able to show that the BCR-ABL protein directly phosphorylates STAT5, thereby activating it.

As Superti-Furga notes, "The findings have extremely important consequences for CML therapy in humans," adding, "We are very happy that the collaboration between our two groups is so fruitful". Put bluntly, leukaemia patients that do not respond to imatinib will not be helped by inhibiting JAK2. Interestingly, some JAK2 inhibitors do slow the progression of leukaemic cells, although they must be given at very high levels. The "therapeutic" action is mediated by a secondary target of the JAK2 inhibitors, which Sexl and colleagues have shown to be the Bcr-Abl oncogene itself. Sexl concludes that, "at the moment there is simply no rationale for giving leukaemic patients JAK2 inhibitors. If we want to help patients who do not respond to imatinib, we should concentrate instead on developing inhibitors to STAT5."

###

University of Veterinary Medicine -- Vienna: http://www.vetmeduni.ac.at

Thanks to University of Veterinary Medicine -- Vienna for this article.

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Source: http://www.labspaces.net/117176/Jak_of_all_trades___Not_of_leukaemia_therapy_

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