Researchers find possible genetic clues to organ development, birth defects

Tuesday, February 12, 2013

Using cutting-edge time-lapse photography, University of Southern California (USC) researchers have discovered clues to the development of the head at the cellular level, which could point scientists to a better understanding of how organs and birth defects form in humans.

A team of researchers at the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC has for the first time determined the role of two important molecular signaling pathways that help control the number and position of repeated units of cells that pattern the head and face.

Two members of a "Wnt" signaling pathway are instrumental in forming pharyngeal pouches that organize the structure of the head and face. Problems with forming the pouches can result in birth defects, including the rare DiGeorge syndrome, which causes an array of symptoms including an abnormal facial appearance, cleft palate, congenital heart disease, and loss of the thyroid and thymus.

The research, "Wnt-Dependent Epithelial Transitions Drive Pharyngeal Pouch Formation," was published Feb. 11, 2013 in Developmental Cell. Principal author is Chong Pyo Choe, research associate at the Keck School of Medicine of USC.

The research, conducted over a five-year period, was accomplished by photographing live zebrafish embryos every 10 minutes for 36-hour periods with a sophisticated microscope, enabling the researchers to see the pouches forming in real time, said Gage Crump, assistant professor in cell and neurobiology, and corresponding author on the research.

"Zebrafish and humans are similar at the genetic level and the organ level," Crump said. "They have almost all the same organs that we do, which makes the fish a very relevant system for understanding human health and disease."

The pharyngeal pouches develop the gills in fish, and in human fetuses they also form gill-like structures, which later organize the head skeleton and organs such as the thymus and thyroid. Birth defects like DiGeorge syndrome can be traced back to malformations in the development of the pharyngeal pouches, Crump said.

Choe developed more than 100 different transgenic lines, transferring key genes to live zebrafish embryos where they could be studied under the microscope at the single cell level. Surprisingly, the lengthy filming doesn't harm the embryos and they can grow up to be normal fish, Crump said.

Using cutting-edge time-lapse photography, University of Southern California researchers have discovered clues to the development of the head at the cellular level, which could point scientists to a better understanding of how organs and birth defects form in humans.Credit: University of Southern California

The Wnt pathways are significant because they control two separate cell behaviors. Choe discovered this by finding a way to genetically block each pathway and then making time-lapse videos of how development went wrong in each case.

"In the future as we get better at harnessing stem cells to create organs, we hope to be able to bioengineer these cells to make a particularly shaped organ," Crump said. "What we're learning in zebrafish by studying these pouches will be generally applicable and we can pursue these basic principles to come up with new types of technology involving cellular therapy."

The team is now studying other signaling pathways and their possible contributions to organ development and defects.

###

Choe, C.P., Collazo, A., Trinh, L., Pan, L., Moens, C.B., Crump, J.G. Wnt-Dependent Epithelial Transitions Drive Pharyngeal Pouch Formation. Developmental Cell. Published Feb. 11, 2013; doi.org/10.1016/j.devcel.2012.12.003

University of Southern California - Health Sciences: http://uscnews.usc.edu/archives/health/

Thanks to University of Southern California - Health Sciences for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/126742/Researchers_find_possible_genetic_clues_to_organ_development__birth_defects

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Team braves wet, cold retracing Shackleton's steps

In this Jan. 23, 2013 photo released by Shackleton Epic, adventurers aboard their boat Alexander Shackleton leave Elephant Island. A modern-day team of six led by Tim Jarvis and Barry "Baz" Gray used similar equipment and clothes to re-enact a 1916 expedition led by Ernest Shackleton to save his crew after their ship got stuck in Antarctica?s icy waters. They reached an old whaling station on remote South Georgia island Monday, Feb. 11, 2013, 19 days after leaving Elephant Island. Just as Shackleton did in 1916, Jarvis and his team sailed 800 nautical miles across the Southern Ocean in a small lifeboat and then climbed over crevasse-filled mountains in South Georgia. (AP Photo/Shackleton Epic, Jo Stewart)

In this Jan. 23, 2013 photo released by Shackleton Epic, adventurers aboard their boat Alexander Shackleton leave Elephant Island. A modern-day team of six led by Tim Jarvis and Barry "Baz" Gray used similar equipment and clothes to re-enact a 1916 expedition led by Ernest Shackleton to save his crew after their ship got stuck in Antarctica?s icy waters. They reached an old whaling station on remote South Georgia island Monday, Feb. 11, 2013, 19 days after leaving Elephant Island. Just as Shackleton did in 1916, Jarvis and his team sailed 800 nautical miles across the Southern Ocean in a small lifeboat and then climbed over crevasse-filled mountains in South Georgia. (AP Photo/Shackleton Epic, Jo Stewart)

In this Jan. 16, 2013 photo released by Shackleton Epic, adventurers aboard their boat Alexander Shackleton train sailing in the Southern Ocean. A modern-day team of six led by Tim Jarvis and Barry "Baz" Gray used similar equipment and clothes to re-enact a 1916 expedition led by Ernest Shackleton to save his crew after their ship got stuck in Antarctica?s icy waters. They reached an old whaling station on remote South Georgia island Monday, Feb. 11, 2013, 19 days after leaving Elephant Island. Just as Shackleton did in 1916, Jarvis and his team sailed 800 nautical miles across the Southern Ocean in a small lifeboat and then climbed over crevasse-filled mountains in South Georgia. (AP Photo/Shackleton Epic, Ed Wardle)

In this Feb. 11, 2013 photo released by Shackleton Epic, expedition leader Tim Jarvis poses on the deck of their boat Alexander Shackleton in the Southern Ocean. A modern-day team of six led by Jarvis and Barry "Baz" Gray used similar equipment and clothes to re-enact a 1916 expedition led by Ernest Shackleton to save his crew after their ship got stuck in Antarctica?s icy waters. They reached an old whaling station on remote South Georgia island Monday, Feb. 11, 2013, 19 days after leaving Elephant Island. Just as Shackleton did in 1916, Jarvis and his team sailed 800 nautical miles across the Southern Ocean in a small lifeboat and then climbed over crevasse-filled mountains in South Georgia. (AP Photo/Shackleton Epic, Alex Kumar)

In this July, 13, 2012 photo released by Shackleton Epic, expedition members pull their boat ashore on Elephant Island during their training. A modern-day team of six led by Tim Jarvis and Barry "Baz" Gray used similar equipment and clothes to re-enact a 1916 expedition led by Ernest Shackleton to save his crew after their ship got stuck in Antarctica?s icy waters. They reached an old whaling station on remote South Georgia island Monday, Feb. 11, 2013, 19 days after leaving Elephant Island. Just as Shackleton did in 1916, Jarvis and his team sailed 800 nautical miles across the Southern Ocean in a small lifeboat and then climbed over crevasse-filled mountains in South Georgia. (AP Photo/Shackleton Epic, Jo Stewart)

In this Jan. 23, 2013 photo released by Shackleton Epic, adventurers aboard their boat Alexander Shackleton cross the Southern Ocean. A modern-day team of six led by Tim Jarvis and Barry "Baz" Gray used similar equipment and clothes to re-enact a 1916 expedition led by Ernest Shackleton to save his crew after their ship got stuck in Antarctica?s icy waters. They reached an old whaling station on remote South Georgia island Monday, Feb. 11, 2013, 19 days after leaving Elephant Island. Just as Shackleton did in 1916, Jarvis and his team sailed 800 nautical miles across the Southern Ocean in a small lifeboat and then climbed over crevasse-filled mountains in South Georgia. (AP Photo/Shackleton Epic, Si Wagen)

WELLINGTON, New Zealand (AP) ? It's been lauded as one of the greatest survival stories of all-time.

Nearly 100 years later, a group of British and Australian adventurers have discovered why. They re-enacted Ernest Shackleton's journey to save his crew when their ship got stuck and sank in Antarctica's icy waters.

Tim Jarvis and Barry "Baz" Gray reached an old whaling station on remote South Georgia island Monday, 19 days after leaving Elephant Island. Just as Shackleton did in 1916, Jarvis and his team sailed 800 nautical miles (1,300 kilometers) across the Southern Ocean in a small lifeboat and then climbed over crevasse-filled mountains in South Georgia.

The modern-day team of six used similar equipment and clothes. But the harsh conditions forced several of them to abandon their attempt along the way.

"It was epic, really epic, and we've arrived here against the odds," Jarvis told his project manager Kim McKay after reaching the station, adding that "we had more than 20 crevasse falls up to our knees and Baz fell into a crevasse up to his armpits."

McKay said Jarvis was suffering frostbite in his right foot after the journey. He planned Tuesday to hike to the grave site of Shackleton, who was buried on the island years after his journey.

Jarvis wasn't the only one suffering foot problems. Three of the men couldn't complete the climb after suffering the ailment trench foot, caused by prolonged exposure to cold and wet conditions.

"The boat was only 22? feet (6.8 meters) long. At any one time, only four men could be below deck, while the other two had to be on deck. They had 8-meter (26-foot) waves crashing onto the boat," McKay said. "It was like they were playing a game of twister. If one moved, they all had to move. They were constantly wet and cold and they all arrived with varying degrees of trench foot."

Shackleton completed the climb without a tent. Jarvis and his team were planning to do the same but were forced to use modern-day tents and sleeping bags when a blizzard hit. One member of the team turned back and then later rejoined Jarvis and Gray with more provisions and wearing modern-day clothing.

Shackleton's survival story was remarkable in that the final two legs of his journey came after the 28 crew had endured more than a year in Antarctica. Their ship "Endurance" was trapped and then crushed by the ice pack and the men later sailed in lifeboats to Elephant Island, where 22 of them stayed, waiting for help. After reaching the whaling station, Shackleton was able to raise the alarm and save all his crew.

While Jarvis, who lives in Australia and also has British citizenship, and his team tried to recreate many of the conditions, there were limits ? they decided to eat salami rather than the penguins and seals on which Shackleton's crew subsisted.

"These early explorers were iron men in wooden boats," Jarvis told McKay, adding that he hoped "we've been able to emulate some of what they achieved."

___

Follow Nick Perry on Twitter at http://twitter.com/nickgbperry

Associated Press

Source: http://hosted2.ap.org/apdefault/aa9398e6757a46fa93ed5dea7bd3729e/Article_2013-02-11-Antarctica-Shackleton%20Re-enactment/id-d27690384c15429682eb1307c0225a24

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GOP congressman invites Ted Nugent to Obama speech

WASHINGTON?A Republican congressman says he's invited rocker Ted Nugent, who has referred to President Barack Obama's administration as "evil, America-hating," to the State of the Union address.

Rep. Steve Stockman of Texas said Monday on his website that Nugent will be his guest for the president's speech Tuesday night. Stockman has talked of impeaching Obama over his gun control proposals.

In a speech to the National Rifle Association during the 2012 campaign, Nugent said that if Obama were re-elected, the longtime gun-control opponent would either be "dead or in jail."

Nugent's remarks led to meetings with representatives of the Secret Service.

Rep. Luis V. Gutierrez said another guest would be Gabino Sanchez of South Carolina. Gutierrez described Sanchez as a husband, father and an illegal immigrant fighting deportation.

Source: http://feedproxy.google.com/~r/dp-politics/~3/YK9q43O799c/gop-congressman-invites-ted-nugent-obama-speech

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Russian coal mine blast kills 18: Interfax

MOSCOW (Reuters) - An underground explosion killed 18 people in a Russian coal mine on Monday, Interfax news agency quoted an Interior Ministry official as saying.

"According to preliminary information ... 18 people died, 10 of whom have been brought to the surface," Interfax quoted an official at the ministry's press department as saying.

The mine belongs to a division of Severstal, one of Russia's largest steel producers.

(Reporting by Thomas Grove, Editing by Timothy Heritage)

Source: http://news.yahoo.com/eighteen-miners-feared-trapped-russian-pit-blast-074322540.html

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10 dead in stampede at Hindu festival in India

ALLAHABAD, India (AP) ? A stampede killed at least 10 people and injured a dozen more in an Indian train station flooded with people during a Hindu festival that attracts millions.

Indian Railway Minister Pawan Bansal said the stampede happened in the Allahabad train station on Sunday evening. News reports said tens of thousands of people were in the station when a section of a footbridge there collapsed, leading to the stampede.

Indian media outlets reported higher tolls later, saying about 20 people died and 30 others had been injured.

Television showed large crowds pushing and jostling at the train station as policemen struggled to restore order.

"There was complete chaos. There was no doctor or ambulance for at least two hours after the accident," an eyewitness told NDTV news channel.

An estimated 30 million Hindus were expected to take a dip at the Sangam, the confluence of the Ganges, the Yamuna and the mythical Saraswati rivers on Sunday, one of the holiest bathing days of the Kumbh Mela, or Pitcher Festival. The festival lasts 55 days and is one of the world's largest religious gatherings.

The auspicious bathing days are decided by the alignment of stars, and the most dramatic feature of the festival is the Naga sadhus ? ascetics with ash rubbed all over their bodies, wearing only marigold garlands ? leaping joyfully into the holy waters.

According to Hindu mythology, the Kumbh Mela celebrates the victory of gods over demons in a furious battle over nectar that would give them immortality. As one of the gods fled with a pitcher of the nectar across the skies, it spilled on four Indian towns_Allahabad, Nasik, Ujjain and Haridwar.

The Kumbh Mela is held four times every 12 years in those towns. Hindus believe that sins accumulated in past and current lives require them to continue the cycle of death and rebirth until they are cleansed. If they bathe at the Ganges on the most auspicious day of the festival, believers say they can rid themselves of their sins.

____

Associated Press writer Biswajeet Banerjee contributed to this report.

Source: http://news.yahoo.com/10-dead-stampede-hindu-festival-india-172028808.html

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Technical Debt Will Kill You Dead (If You Let It)

A project I've been working on launched recently. Well, re-launched. A slick little iPhone app called Postography, which lets you send postcards with messages and pictures from your iPhone. Nifty, but sounds fairly straightforward, right? An app that shouldn't have taken too much time to build. Unfortunately, we didn't build it; we rebuilt it. And the company that took the first crack at it (naming no names here) did a fairly good job on the server side...but epically botched the initial version of the app itself.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/kT_3S0vnhXo/

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The problems of job searching and how not to go crazy | Cup of Tea ...

Last month I attended a student conference on digital preservation that was geared towards giving us advice on how to get in to a career in this area.

A theme that a few of the speakers touched on was the need to look for jobs outside the usual jobs titles.? For example, a job with the BBC digital sound archive was recently advertised under the title of ?Media Manager?.? Would you see that job and think, that will require my skills I?ll look closer?

This disparity between the job titles and what the job actually involves was discussed in a number of ways, but the primary area that interested me was during the round table discussion at the end when a few points were raised about how exactly we?re supposed to find these jobs if they have such vague job titles.

It was suggested by one of the panel members that we need to read the job descriptions to find out more.? This is of course an obvious and very true statement but a number of attendees felt this was not a practical solution due to the number of jobs being advertised.

For me this all brought up the question of where people look to find jobs?especially?if you?re not necessarily interested in working within a traditional library setting.

I asked my Twitter followers where they searched for jobs and I am indebted to all of them (credits at the end) for their suggestions and opinions.

It seems that the best approach to job searching is not to limit yourself to looking in only one place but to employ a diverse strategy of searching in a number of places that may be of use to you.

Below is a look at different approaches to searching for jobs and the pros and cons of each way.? It is important to note that some ways work very well for some people but it might not work for you, so job searching is all about getting the best out of these resources for yourself.

Specific company search.

You know you want to work for the British Library or Oxford University so you can just search their websites, right?? Well, of course you can do that, but you would be severely limiting yourself to only a few jobs. And your chances of getting (or finding new) employment would be restricted.? If you know you can only apply for jobs in one area (for example, London) then you can search the websites of all universities in London.? Of which there are a lot!? This is time consuming but not impossible.? But what about all the other places you could work.? Companies? Schools? Colleges? Charities?? You could do a search of a select few of these, but how many law firms will hire information specialists?? (Lots, by the way). Can you really search all of their websites?

Doing a company specific search alone only works if you only want to work for a handful of companies. ?If this is your ideal, then that is fine.? But I think for the majority of job searchers it would fall short of being totally adequate.

It is important to keep in mind that some companies only advertise on their own websites and a lot of universities don?t advertise junior posts (i.e library assistant/shelver positions) anywhere else. Picking a few company websites to directly get job listings from (preferably by rss or signing up to email alerts to save you time) is a useful addition to your job search techniques.

Tips: If you know which geographical area you?re looking in you could find the biggest companies and search them.? You could also add companies that you know don?t advertise elsewhere (or that have limited jobs appearing on other sites), for example, The British Library, BBC, etc?

Sector specific aggregators

Lisjobnet is the most useful website if you want to work in a library.? Although it says it is also for information jobs I have not found it particularly useful for any jobs outside the traditional areas.? It does seem very focused on library work and also for middle to higher positions.? I have many times found library assistant posts on other websites that are not on here.? There is also a similar problem with jobs.ac.uk.? Obviously this site is focused entirely on jobs within academic institutions and you can browse specifically in the sector you want.? However, I have also found jobs that required information researching/management skills which were in other categories.? Both of these sites have the bonus that you can sign up for email alerts which saves a lot of the bother of having to go and physically search the site yourself.? However, as already mentioned, they do seem limited in their scope.

Jobsforinfopros is useful for jobs in the wider sector, though it does just seem to aggregate from employment agencies and is very London focused.? Additionally, their service to sign up for email alerts requires you to a fill out a form which insists on only a few geographic areas being picked and on you stipulating a wage.? It you want complete flexibility in your search and aren?t that picky then this is completely useless.

Tips: see below ?General jobs sites?

General jobs sites

These type of sites cause me the greatest headache.? If a job that requires a library/information/archive qualification (or just experience) isn?t within a traditional setting sometimes the employer might not advertise it on a specialist website there but they might advertise on (for example) monster, totaljobs, Indeed etc? The problem with this is then searching for jobs.? What exactly do you search for?? You can?t possibly view every job on there, there are thousands.? If you try to limit your search by keywords what keywords do you choose?? Library? Archive? Information?? You will probably find all of these so vague that they come up with 1000s of results.? And as already mentioned above, many jobs now don?t feature key words in their title, so you need to search for key words in the job description.

I personally don?t find these searches targeted enough.? In one search for ?library assistant? I came up with 1869 results only 5 of which seemed to be what I was looking for, I?m not even sure how the rest ended up there as they weren?t relevant at all.

The best of these generic search sites I have found is Indeed.co.uk.? It also comes highly recommended by my Twitter followers.? It draws in jobs from a variety of sources and doesn?t seem to be dependent on companies adding the jobs to the site themselves (as Monster does).? I found that setting up email alerts for quite a few different search terms the best way to use the site.

Tips: If you?re not finding many jobs in one category try looking around in others for anything of interest. Set up email alerts if you can so you don?t have to do much legwork to get the latest jobs.? If you?re doing a key word search try not to stick to just one term, ?librarian? may come up with fewer results then ?library?.? Searching for generic terms such as ?information? may come up with a few information assistant roles but may also come up with thousands of irrelevant posts in which you can miss the few good ones, so sometimes being specific works better.? If you?re looking at a sector specific site which lists a vague job title, click on it and have a quick scan at the description, it might not be what you think it is.

Social Media

There are a few Twitter accounts that list jobs such as @uklibraryjobs but I don?t know of any companies who tweet their own job vacancies (on an account dedicated to vacancies only).? As an avid Tweeter I do need to remind myself constently that most people are not on Twitter, and even when companies are not all of them use it in the most productive way.? I would not recommend relying on Twitter for finding jobs.? Like all of the suggestions above it can be another way to search for jobs without really trying as they will pop up in your feed amongst gin and knitting discussions (I?m not being stereotypical, this is what my timeline looks like today).

I have no knowledge of any companies using Facebook to advertise vacancies so I did some quick investing whilst writing this blog post [pause to go off to Facebook and work out what to say next] and I can find nothing.? Anyone any the wiser please let me know.

Linkedin could be such a useful site?.jobs directly related to courses you have listed or key skills tagged could be shown to you in a coherently ordered manner.? Except, it doesn?t work like that.? A lot of American companies use it and I think it could become useful if more UK companies were to get on board with it.? I don?t think they will as people don?t seem to use it for job search, so it?s a vicious circle.

With all these social media opinions I?m really only using my own experience so I may have completely missed the boat on something?please use the comments to let me know of anything I?ve forgotten or that I?m just plain wrong about.

Tips: It?s worth following any companies on Twitter you particularly like the idea of working for, they may tweet job posts but you?ll also keep up to date with the latest news from them.? You don?t need to have a twitter account to look at accounts advertising jobs, though it will save you time if you get an account and follow them all, then there?ll all appear in a nice easy list without you having to click on each one individually.

Employment agencies

These are a great source of sector specific jobs though you need to use them slightly differently to how you would a straightforward job advert.? Although they will feature job adverts on site it is important to alo register yourself with the agency (get in touch and send them your CV) as a lot of their jobs will be sent directly to their clients before being put online.

I think there is a perception that a lot of agency jobs are temporary and require immediate starts.? Whilst this is true of a lot of agencies, they do all differ, and most of them also have permanent jobs too.

Tips:? I?ll repeat as mentioned about, don?t just rely on searching agencies websites, most of their jobs don?t end up there.? Register with them and if you don?t feel like they?re sending you many job openings speak to them directly as they may have misunderstood what type of position you?re looking for.

Word of mouth/networking

This is something I always forget about but was mentioned to me on Twitter this morning.? If people know you?re on the look out for a job they are quite likely to send your way anything they see that may be suitable for you.? I find this works very well on twitter, as people will tend to re-tweet or post jobs they see that are interesting which alerts me to these vacancies.

Networking cannot be underestimated for its usefulness in job searching.? If you?re at a conference/training event make sure you speak to people who work in a sector you?re interested in, if they remember you they may be the person you apply for a job with in the future (every little helps). It was suggested to me today that a good estimate is something in the region of 40% of jobs are never advertised, that is worth keeping in mind if you?re ever shy about approaching people. Even if a new job doesn?t come out of networking you are still learning a valuable amount about the sector and this research makes you a stronger candidate and more able to help others in the same position as you.

I will squeeze mailing lists into the section as well.? Quite often jobs will be posted on mailing lists by the people advertising vacancies (or people working in those places).? It?s a good idea to sign up to general and more specific mailing lists for areas you?re interested in working.

Tips: Keep an eye on what people are saying on Social Media, they may mention when there?s jobs going where they work and will also pass on any interesting posts they see whilst doing their own job search.? Keep an ear out for people talking about new projects getting started as it might be worth approaching project managers (or getting an introduction) to be in mind should any new vacancies open up.? If you?re interested in a small sector area, get in touch with people who currently do it, ask for advice, they may know of positions available, or keep you in mind if ones open up in the future.

Suggestions to employers

There is only so much the bedraggled job searcher can do without searching for jobs 24 hours a day and reading every job description on every website.? I have thought of a few ways that employers can make things easier so that the right people see the right jobs and employers get the best people applying.? These may be impractical for employers, but I live in an idealised world in my head where I assume employers want to hire the best people, silly me!

-?????? Try making your job descriptions less generic.? If you really want to call the post Senior Media Manger how about adding an (archives) or (library) in brackets after the title?

-?????? If your job requires specific skills/qualifications why not post it on websites that are dedicated to such people (ie lisjobnet).? Given that is the most viewed job site for people with an LIS qualification (judging by my unscientific pole on Twitter today) why not increase your chances that the right candidate will see if by also posting it there. This is particularly useful if your company is not in a sector that people would traditionally think to look at.

-?????? Add an RSS feed to your website vacancies page.? People are more likely to look at individual companies websites if they have a way to easily get at the information.

-?????? Have a twitter account just for your job vacancies.? Same reason as the above for RSS feeds.? Also, people will re-tweet your vacancies to a wider audience.

-?????? If UK companies would start using Linkedin more, especially to advertise jobs, it would be a practical useful resource, instead of being mostly useless.

So what does this all mean?

I?m afraid there isn?t one website/resource that you will find your perfect job on.? I haven?t even covered looking in newspapers/magazines, using members only sections of professional associations websites, looking at government (local/central) websites, job fairs, career services?.the list is endless.? Most importantly for job seekers is to be alert to others working in the sector (and in parallel sectors too).? They may not tell you directly about a great job you can apply for immediately, but they may alert you to a company you?d never considered working for, a person you should get in touch with, a website you should be reading.? The possibilities are endless!? The key is to find the resources that work for the sector you want to work in and to tailor your searches to suit your needs.?

Key resources

Here is a list of all the different sites/resources I have mentioned above.? Please leave comments about any more you find useful and indeed and more tactics for finding jobs that you would recommend.

Tips for staying sane: ?Where you can, follow websites via RSS feeds so you can aggregate everything into one easy to manage place, or set up email alerts so the vacancies come to you.

Websites: (Links with * are ones specifically recommended to me as good places for library/info jobs)

*http://www.lisjobnet.com/
*http://www.jobsforinfopros.com/
*http://www.suehill.com/ ? Sue Hill Recruitment
*http://www.jobs.ac.uk
http://www.jobs.nhs.uk/
*http://www.glenrecruitment.co.uk/
https://www.gov.uk/jobsearch
http://www.totaljobs.com/
*http://web.jinfo.com/jobs/search/
*http://www.indeed.co.uk/
http://www.monster.co.uk/
http://www.jobsgopublic.com/
http://jobs.guardian.co.uk/
http://www.timewisejobs.co.uk/ ? for part time jobs

Twitter accounts:

https://twitter.com/UKLibraryJobs
https://twitter.com/LibJobsLondon
https://twitter.com/jobsforinfopros
https://twitter.com/LISJOBNET
https://twitter.com/tmj_GBR_library ? this account hasn?t tweeted anything yet but does seem to be new so I?ll be keeping an eye on it.

Other ways to find jobs:

Jisc mailing lists ? http://www.jiscmail.ac.uk/

Thank you to all the following people for answering my appeal for help on Twitter today, your suggestions should have made it to the above post I hope.

Thanks @booleanberry @LibraryPatrick @Girlinthe @HelenMaryH @RareLibrarian1 @ellekaypea @wiley9000 @ErikaDelbecque

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Source: http://teaandscone.wordpress.com/2013/02/09/the-problems-of-job-searching-and-how-not-to-go-crazy/

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